Saturday, April 27, 2013

First Phase Insulin ~ Physiological Relevance?

Something I've been reading a lot lately would be along the lines of "first phase insulin response is deficient/missing from the early stages of diabetes".   This is true, but even in the peer review literature that term seems to be misused to equate with the acute spike in insulin levels to a high oral glucose load.  However the first phase insulin response, hereinafter FPIR, is a non-physiologic phenomenon sometimes used to assess pancreatic function.  

First-phase insulin secretion: does it exist in real life?  Considerations on shape and function  (decluttered  of references, please see origina, some parts bullet-pointed, etc. for clarityl)
IN THE PAST THREE DECADES, the relevance of insulin secretion abnormalities in the pathogenesis of type 2 diabetes mellitus have been extensively debated, and a consensus has been reached that, to fulfill its pivotal role in regulating glucose metabolism, insulin secretion must not only be quantitatively appropriate, but also possess qualitative, dynamic features that optimize insulin action on target tissues. In particular, increasing emphasis has been placed on the importance of the so-called first-phase insulin secretion to glucose homeostasis.  The aim of this review is to address the following questions:
Read more »

No comments:

Post a Comment