Friday, September 9, 2011

Metabolic Mad Libs

Anyone here remember Mad Libs?   These were game books of sentences, short stories even, where you would be asked to fill in the blank with a certain type of word (adjective, noun, profession, color, etc.) and the result would often be a very funny sentence/tale.

Let's take the carbs → insulin → obesity hypothesis and turn it into a Mad Lib.  Although my intent here is not one at humor, but instead to demonstrate how LC logic fails us.  

Here's a starting paragraph one might find in support of TWICHOO.

Insulin drives esterification and the storage of triglycerides in fat cells.  Dietary carbohydrates stimulate insulin therefore stimulate fat storage.  Obesity is associated with high fasting levels of insulin, therefore hyperinsulinemia causes fat accumulation.  Dietary fats don't stimulate insulin therefore fats have no influence on fat accumulation.  A deficiency in insulin [Type 1 diabetes] leads to weight loss.  Therefore, carbohydrates drive insulin drives fat accumulation.  Carbohydrates make you fat.
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