Tuesday, July 3, 2012

Variability & Error (yeah ... and one more time Ebbeling et.al.)

One of the issues raised in recent days is quite important:  How does measurement error factor in?  How does variability in what's being measured factor in?  

Statistical analyses do not address these two things.   I'm not sure which podcast it was, there have been a few, with the dynamic Chris duo (Kresser with Masterjohn), but Chris made the comment {paraphrase big time} that the best way to change your LDL particle size favorably was to have a different test done.  I'd love a link gang, if this rings a bell for you.   LDL is not even measured directly in some (most?  all?) analyses of blood lipids.  So first, Chris addressed the error in the measurement.    And I think they discussed the normal day-to-day variability in the lipoprotein concentrations in that same installment as well.  Now I don't want to put numbers/words in Chris' mouth but I've heard similar statements from countless others -- the number 20 point fluctuations in LDL comes to mind.  
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