Sunday, August 28, 2011

Where do triglycerides come from? Part III

If you haven't done so already, you may want to read Part I and Part II first.  Part II, especially, discusses the sources of fatty acids for VLDL triglycerides manufactured by the liver and two secretory pathways - an immediate one and a delayed one.  In this part I'll discuss the results of that study:



This group uses different radioactive tracers to identify the source the fatty acids in VLDL-triglycerides.  This study differed from the study in Part I in that it looked at prolonged triglyceride levels - fasting and postprandial - rather than just fasting.  For one week prior to the study all subjects were provided a standard diet (outpatient basis) of 50% carb, 35% fat, 15% protein*, at weight maintaining levels.  I would note that this would mean the obese study groups were likely ingesting significantly more than the lean controls.  The study diet followed for 5 weeks essentially replaced 20% of fat energy with carbohydrate energy for approximately 70% carb, 15% fat, 15% protein*.    It was noted that caloric content was similar, simple sugars were the same as a percentage, but absolute simple sugar intake was almost 40% more on the high carb diet.  The high carb diet also contained 50% more fiber and almost 90% less cholesterol.
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