Wednesday, June 1, 2011

The Myth of Starving Cells II ~ Lipolysis is not rate limiting

The low carb theory on weight loss revolves on insulin's action on adipocytes.  Specifically, high insulin favors deposition (esterification to form triglycerides) in the fat cells and suppresses lipolysis (breakdown to free fatty acids).  

This of course is true.  But the problem with this discussion is that it is incomplete.  You see, lipolysis has little to do with fat burning per se.  That is beta-oxidation occurring in the mitochondria in a series of cyclical reactions commonly called the Fatty Acid Spiral, FAS.  Free fatty acids are constantly delivered to the cells and being taken up.  Those that are not oxidized for energy are re-esterified and stored as triglycerides inside the cells (e.g. IMCL or IMCT).
Read more »

No comments:

Post a Comment