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I will forever be grateful to (former?) blogger LynMarie Daye of Adipo Insights blog for bringing the following paper to my attention:
If you're a regular reader and you haven't read it yet, what are you waiting for? If you're a new reader it's a must (unless of course you're just here for the gossip you claim is boring and inappropriate - grin). The article is quite long, but it is written in very understandable fashion. A lot of info, so perhaps best digested in small segments, but well worth the effort.
The article begins with a history lesson about a physiology professor named Sir Edward Schafer, who "appears to have named insulin and described its actions" in a book published in 1916 entitled The Endocrine Organs. Schafer, described a substance with dual and simultaneous functions:
- Autacoid: excitatory or stimulatory, e.g. glucose transport, lipid synthesis
- Chalone: inhibitory, e.g. inhibiting lipolysis, gluconeogenesis, ketogenesis