Thursday, October 3, 2013

The Cause of Hyperglycemia in Type 2 Diabetes

I will forever be grateful to (former?) blogger LynMarie Daye of Adipo Insights blog for bringing the following paper to my attention:

If you're a regular reader and you haven't read it yet, what are you waiting for?  If you're a new reader it's a must (unless of course you're just here for the gossip you claim is boring and inappropriate - grin).   The article is quite long, but it is written in very understandable fashion.  A lot of info, so perhaps best digested in small segments, but well worth the effort. 

The article begins with a history lesson about a physiology professor named Sir Edward Schafer, who "appears to have named insulin and described its actions" in a book published in 1916 entitled The Endocrine Organs.  Schafer, described a substance with dual and simultaneous functions: 
  • Autacoid:  excitatory or stimulatory, e.g. glucose transport, lipid synthesis 
  • Chalone:  inhibitory, e.g. inhibiting lipolysis, gluconeogenesis, ketogenesis
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