I had started this post as a follow-up to my A Matter of Control post before Chris Masterjohn posted the following over on his Daily Lipid blog: When Standing At the Brink of the Abyss, Staring Into the Great Unknown, We Randomize.
I think Chris highlights some of the reasons why randomization is important in studies, but in my opinion, he does overreach some as to the power and purpose of randomization. I'll address those concerns towards the end of this post. Still, his post is spot on regarding two of the important reasons why randomizing is important in studies:
- Selection (self or assigned by investigator) bias, and
- Unknown confounders
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