ABSTRACT: The metabolic balance method was performed on three men to investigate the fate of large excesses of carbohydrate. Glycogen stores, which were first depleted by diet (3 d, 8.35 ± 0.27 MJ [1994 ± 65 kcal] decreasing to 5.70 ± 1.03 MJ [1361 ± 247 kcal], 15% protein, 75% fat, 10% carbohydrate) and exercise, were repleted during 7 d carbohydrate overfeeding (11% protein, 3% fat, and 86% carbohydrate) providing 15.25 1. 10 MJ (3642 ± 263 kcal) on the first day, increasing progressively to 20.64 ± 1 .30 MJ (4930 ± 3 1 1 kcal) on the last day of overfeeding. Glycogen depletion was again accomplished with 2 d of carbohydrate restriction (2.52 MJ/d [602 kcal/d], 85% protein, and 15% fat). Glycogen storage capacity in man is ~15 g/kg body weight and can accommodate a gain of ~500 g before net lipid synthesis contributes to increasing body fat mass. When the glycogen stores are saturated, massive intakes of carbohydrate are disposed of by high carbohydrate-oxidation rates and substantial de novo lipid synthesis (150 g lipid/d using ~475 g CHO/d) without postabsorptive hyperglycemia.
Thursday, April 1, 2010
Glycogen storage capacity and de novo lipogenesis during massive carbohydrate overfeeding in man
Glycogen storage capacity and de novo lipogenesis during massive carbohydrate overfeeding in man.
I just thought this was interesting.
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