In her piece over at MDA on the How Fatty Diets Cause Diabetes, Denise Minger spent a bit of time discussing the strain of mouse used in the study. That being the not-uncute fella you see pictured here: A C57BL/6J mouse. Denise describes these mice as: "uber-susceptible to obesity, high blood sugar, insulin resistance, leptin resistance, and all that other fun stuff plaguing modern humans." This didn't really square with my memory from when I blogged on a study involving this critter. Took me a few minutes to remember what that blog was ... Of Mice and (Wo)Men. That post dealt with a calorie restriction study using this same mouse. In looking for info on this mouse, I had come across this paper: The High-Fat Diet–Fed Mouse. Since I was mostly looking for info on lifespan and such at the time, the subtitle didn't "hit me", that being: A Model for Studying Mechanisms and Treatment of Impaired Glucose Tolerance and Type 2 Diabetes. The paper describes this mouse's propensity towards obesity (and IGT and T2 diabetes) when fed a high fat (58%) diet vs. a standard low fat (11%) chow. However, in the calorie restriction study, these mice did not become obese on standard chow (11%F, 69%C, 20%P, Teklad Global 2016). Therefore I think it would be more fair to say that they are susceptible to diet-induced obesity (DIO), but not obesity per se on a more appropriate diet.
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