Showing posts with label Gary Taubes Fact Check. Show all posts
Showing posts with label Gary Taubes Fact Check. Show all posts

Friday, November 29, 2013

Gary Taubes' Diet Doctor

Since it's the day after turkey day ...
And since I thought I'd lighten up the mood a bit ...

Flashback!  Remember when Gary Taubes had his cholesterol test done by a quack diet doc?!    Enjoy!!

Turns out now he's selling alpha-keto glutarate anti-binge packs.  Very interesting the company some keep ...

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Tuesday, November 19, 2013

All I Want for Christmas ...

A short break to share some things I've been doing "just for fun".  Some people collect classic works of art.  Some literature.  One thing this blog gig has done to me is it has turned me into a collector of old scientific literature!  Thank you Gary Taubes.  Seriously!

Maybe it's my training, but I am a reference hawk.  When I read "new" things, use of quotes to denote that these things are not necessarily new, just new to me, I like to track down sources before proceeding.  This is, after all, the purpose of referencing. 
In 1965, the American Physiological Society published an eight-hundred-page Handbook of Physiology dedicated to the latest research on adipose-tissue metabolism. As this volume documented, several fundamental facts about the relationship between fat and carbohydrate metabolism had become clear. First, the body will burn carbohydrates for fuel, as long as blood sugar is elevated and the reserve supply of carbohydrates stored as glycogen in the liver and muscles is not being depleted. As these carbohydrate reserves begin to be tapped, however, or if there’s a sudden demand for more energy, then the flow of fatty acids from the fat tissue into the circulation accelerates to take up the slack. Meanwhile, a significant portion of the carbohydrates we consume and all of the fat will be stored as fat in our fat cells before being used for fuel. It’s this stored fat, in the form of fatty acids, that will then provide from 50 to 70 percent of all the energy we expend over the course of a day. “Adipose tissue is no longer considered a static tissue,” wrote the Swiss physiologist Albert Renold, who coedited the Handbook of Physiology; “it is recognized as what it is: the major site of active regulation of energy storage and mobilization, one of the primary control mechanisms responsible for the survival of any given organism.” Since the excessive accumulation of fat in the fat tissue is the problem in obesity, we need to understand this primary control mechanism.
Gary Taubes in Good Calories, Bad Calories 
Kindle Locations 7836-7847

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Wednesday, October 23, 2013

Revelations from Gedankenexperiments vs. Wirklichenlebenexperiment

Traffic Bump!

Occasionally I see traffic to old posts whilst perusing stats.  I saw this was getting a few hits and decided to bump it.  Especially since the fervor for finding the single bogeyman dietary agent of all doom seems to be hitting a fever pitch lately.  Even Dr Oz is getting on board, and as the Judith Mazel of the low carb world tells us:
Dr Oz is one of the most well respected conventional doctors—and he has major influence because he is educating millions of people every single day on his show.
{you can stop laughing now ...}
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Saturday, September 14, 2013

Today is a very special day ...

... no longer does the name Gary Taubes hold a position in the five most popular posts of all time here.  

I think that's a good thing.  His ill-conceived hypothesis that is unsupported by a plethora of solid scientific evidence is no longer a hot topic in the carb-wars on the internet.  I see that as a good thing, because despite convincing some hedge fund guys to fund NuSI, it never was much of a hot topic in the real world.  

My work here is done.
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Monday, August 26, 2013

Will NuSI clear the bar?

Gary Taubes is out with a new article in Scientific American ... rehashing the same old same old, and essentially getting paid to write a press release for NuSI.  

What Makes You Fat: Too Many Calories, or the Wrong Carbohydrates?

Rigorously controlled studies may soon give us a definitive answer about what causes obesity—excessive calories or the wrong carbohydrates

We get the rehashing of how WWII stopped Bergmann and Bauer's Lipophilia Hypothesis from becoming the working hypothesis for obesity, and yet another primer on calories vs. carbohydrates.  We again are asked to ignore the obvious -- that Americans are definitely eating more, on average, with no concurrent need for those calories, and likely moving a bit less as well.   The obesity epidemic that supposedly was instigated by the low fat craze is blamed on the fact that much of our additional caloric load is in the form of carbohydrates.  This is not supported by one of Gary Taubes' own paradoxical cultures, the Pima, who did not eat a low carb diet prior to the 1900's, let alone billions of humans all over the globe.   Or .... despite the "modern paleo's" insistence, the paleolithic diet in the literature -- both cited for the basis of the diet and that used in clinical trials.  
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Wednesday, July 31, 2013

Open scientific discourse ...

I'd like to respond to this e-mail and clarify your understanding of the science, but I'd like to do it privately to you. If you promise that's the case, then I will respond. If you then argue persuasively that there is a good reason why your readers would benefit from reading my e-mail, I will agree but I reserve the right to decide what's persuasive or not and what's a good reason.
Memories .... 

Saturday, July 6, 2013

Partial inhibition of adipose tissue lipolysis improves glucose metabolism and insulin sensitivity without alteration of fat mass.

{shhhhhhhhh .... don't tell Gary Taubes, this might just upset his 21DaySugarDetox approved green apple cart!}

You know how the story goes by now, right? In more recent lectures, Taubes is fond of using the slide below.


source
These are two quotes that Taubes cites from Lehninger's Principles of Biochemistry and he juxtaposes them to convince you how misguided such textbooks are.  How can, on the one hand fat cells "fatten" according to the action of insulin, but human beings get fat due to positive energy balance?   The simple answer is that insulin is not some renegade hormone and your pancreas is not a master organ in the body placating your rebellious adipocyte's every whim.

Yes, tis true that insulin has a stimulatory role in the storage of fatty acids by acting on LPL on the intake side, and yes, tis true that insulin "traps" those fatty acids in the adipocytes by suppressing HSL mediated lipolysis and release of same.  Sounds like a slam dunk.  If there's too much insulin, ostensibly from chronic spiking due to chronic carbohydrate consumption, the fat cells get stuck in storage mode and the horizontal growth disorder is primed for obesity!

Not so fast.  How can the results of this study be then?  Partial inhibition of adipose tissue lipolysis improves glucose metabolism and insulin sensitivity without alteration of fat mass.   The abstract, bullet-pointed for ease of reading:
  • When energy is needed, white adipose tissue (WAT) provides fatty acids (FAs) for use in peripheral tissues via stimulation of fat cell lipolysis. 
  • FAs have been postulated to play a critical role in the development of obesity-induced insulin resistance, a major risk factor for diabetes and cardiovascular disease. However, whether and how chronic inhibition of fat mobilization from WAT modulates insulin sensitivity remains elusive. 
  • Hormone-sensitive lipase (HSL) participates in the breakdown of WAT triacylglycerol into FAs. HSL haploinsufficiency and treatment with a HSL inhibitor resulted in improvement of insulin tolerance without impact on body weight, fat mass, and WAT inflammation in high-fat-diet–fed mice. 
  • In vivo palmitate turnover analysis revealed that blunted lipolytic capacity is associated with diminution in FA uptake and storage in peripheral tissues of obese HSL haploinsufficient mice. 
  • The reduction in FA turnover was accompanied by an improvement of glucose metabolism with a shift in respiratory quotient, increase of glucose uptake in WAT and skeletal muscle, and enhancement of de novo lipogenesis and insulin signalling in liver. 
  • In human adipocytes, HSL gene silencing led to improved insulin-stimulated glucose uptake, resulting in increased de novo lipogenesis and activation of cognate gene expression. 
  • In clinical studies, WAT lipolytic rate was positively and negatively correlated with indexes of insulin resistance and WAT de novo lipogenesis gene expression, respectively. 
  • In obese individuals, chronic inhibition of lipolysis resulted in induction of WAT de novo lipogenesis gene expression. 
  • Thus, reduction in WAT lipolysis reshapes FA fluxes without increase of fat mass and improves glucose metabolism through cell-autonomous induction of fat cell de novo lipogenesis, which contributes to improved insulin sensitivity.
Cliff Notes Version:  Decreased lipolysis from WAT increased skeletal muscle glucose uptake and DNL in the liver without resulting in increased WAT mass.  In the obese, suppressing WAT lipolysis induces DNL in the fat tissue.  This improves glucose metabolism.

All of the evil things you were told insulin did to you -- turning carbs to fat in your liver and fat tissue and suppressing lipolysis from fat tissue -- are actually good for you.  And the (temporary) trapping of fat in the adipose tissue improves insulin signaling and glucose handling in the skeletal muscle.  

Imagine that ...


Thursday, July 4, 2013

July 4, 2013 Over the Hump Bump: Where does insulin resistance start? The adipose tissue

The readership in this blog continues to grow and it is not lost on me that a vast majority of current readers are unfamiliar with the bulk of my work here on this blog.  I think I'm closing in on 1000 posts which would make me one of the more prolific bloggers around ... for better or worse!  As such, I more than understand that it would be darned near impossible to catch up, etc.  So a few comments in that vein.  
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Monday, July 1, 2013

Calories ...

... or joules or ergs or foot·lbs or BTUs or eV or ...

These are all the same thing folks.  They are all units of energy. That we use different terms in different contexts doesn't mean we are talking about different things.  It's like different languages, be it vida or leben or liv or อายุการใช้งาน ... they all mean life.

The bastardizing of basic science in the Paleo and LLVLC realms is both ubiquitous and unrelenting.  This is what prompted me to start this blog.  I could really care less about the diet fads that come along that are obvious quackery, but this community is built on "our science is better" or "we understand the science", so wouldn't it be nice if that science is correct?
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Monday, June 17, 2013

That 5000 Calorie Jokesperiment

Note:  I started this article with the intent of it being a single stand-alone before Smash the Fat's Sam Feltham had done his final summary of his overeating stunt.  Since then, however, he has written said summary and I've written two posts discussing this disconnect between the you-can-eat-all-the-calories claims and the current uber-restrictive low carb plans many long time low carbers are actually following themselves.  See:  Fast or Feltham and Fast or Feltham II


Apologies in Advance:  I wrote this with updates/edits over several days and with "new information" coming in the interim.  It could probably use a good bit of editing and crunching down, but as this is just a blog, I'm going to publish it up w/o wasting time on that.  Please forgive the length, repetitiveness, etc.  Thanks!


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Must See "TV" for those suffering from CDS

BUMP!  Original posting:  1/24/11

CDS = Calorie Denial Syndrome

BBC Story about Low Carb Dieting - Part 1
BBC Story about Low Carb Dieting - Part 2
BBC Story about Low Carb Dieting - Part 3
BBC Story about Low Carb Dieting - Part 4
BBC Story about Low Carb Dieting - Part 5

(HatTip to Wolfstriked for linking to this in comments.)

Just a few thoughts on this aside from the content so that my opinions will not cloud your listening of the presentation:

I found it interesting that they showed both Westman and Foster exercising (running and playing basketball) in their intros in the piece.  Indeed they are interviewed in their gym clothes!  Then there's Dr. Mary Vernon horseback riding.  Did we need so many closeup chewing scenes?  And, lastly, was the full rear (albeit blurred) Sipowitz moment in the shower, actually that rather lengthy soaping/showering scene, really necessary as a backdrop to the discussion of ketosis?




Friday, June 7, 2013

The Myth of Starving Cells II and NEFA Levels Again.

UPDATE (and a tiny bump for feed subscribers):  I noticed a bit of traffic to a prior related post, so I'm just linking to that one here as well:  Insulin Doing Its Thang! And Still No Starving Cells.  It discusses another study by Keith Frayn that shows increased NEFA uptake into the muscle cells of men with hyperinsulinemia.  It may be worth a read for newer readers along with The Myth of Starving Cells.


Original Content:

A little sidetrack here, but I came across an article the other day. I just had to blog on it before I forgot!  

A little background as well -- A couple of years ago I wrote:  The Myth of Starving Cells.  As the story goes, as related by science journalist Gary Taubes, to Low Carb Diet Doctor Mike Eades, to Fat Head Naughton, insulin traps our fat in our fat cells, causing "internal starvation" as the rest of our cells go without, triggering hunger and overeating.   We overeat because we are getting fat, or some nonsense like that.   In the post, I discussed studies demonstrating the opposite is true.  In obesity, there is failure to properly suppress NEFA release from fat cells, NEFA are elevated in the fasted state, and irrespective of absolute concentration, NEFA delivery to cells is higher.  The last point leading to accumulation of fat within ectopic cells, such as muscle cells (called intramyocellular triglyceride or lipid, IMTG, IMCT or IMCL).  The cells have plenty of fat fuel to burn ... indeed this is a problem!

So I was looking for a  link to that Ebbeling et.al. study the other day -- this one: Effects of Dietary Composition on Energy Expenditure During Weight-Loss Maintenance.  In the study, a group of obese people were put on a relatively high protein (25%), relatively low fat (30%) and moderate carb (45%) diet and lost between 10 and 15% of their initial body weight.  After which they were weight stabilized and then fed one of three maintenance diets for 4 weeks in randomized cross-over fashion.  These diets were P/F/C:  low fat = 20/20/60 , low GI = 20/40/40, and low carb = 30/60/10.  
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Monday, June 3, 2013

GCBC Reference Check ~ Part VIII of ? ~ The Paleo Diet

Preface:  When I first read GCBC some time in 2009, I skimmed over the parts that were irrelevant to my issues with the book, which were on the basis of Taubes' misrepresentations of metabolism and obesity, etc.  In the intervening years I've gone back and read large chunks of it in more detail, but if I ever read the parts about the Paleolithic, I didn't take much note at the time because the names were not familiar to me.  

I've always found it odd how Taubes was described as paleo in some circles, his book is even cited on an infographic listing 10 years of paleo literature!  Aside from calling out refined carbs and sugar quite a bit, Taubes doesn't really make much of a deal about quality of foods, especially fats.  (Shhhhhh, don't tell the paleo peeps, but peanut oil is listed as an "especially healthy" oil in WWGF - Kindle Locations 3423-3424)
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Saturday, June 1, 2013

Another Great Quote


In reality, those who repudiate a theory that they had once proposed, or a theory that they had accepted enthusiastically and with which they had identified themselves, are very rare.   The great majority of them shut their ears so as not to hear the crying facts, and shut their eyes so as not to see the glaring facts, in order to remain faithful to their theories in spite of all and everything. 
MAURICE ARTHUS,
Philosophy of Scientific Investigation, 1921








Taubes, Gary (2007-09-25). Good Calories, Bad Calories (Kindle Locations 1514-1518). Knopf Doubleday Publishing Group. Kindle Edition. 

Monday, May 13, 2013

Stick a Toothpick in It? Taubes' 4-pronged Carb/Insulin "Fork" Loses its Tines

I'm bumping this today, because in the weeks to come I hope to update, flesh out, and reference it fully.  Looking back at something written almost 2 and a half years ago it seems rough, but nonetheless it  still summarizes what I call TWICHOO and the arguments against it pretty well.  



This post updated slightly 6/22/2012.   Original publication date 1/23/11

In the comments at Jimmy's blog on my interview podcast, several comments either directly or by inference say I failed to make my case against Taubes.  Well, I think I did pretty much get to what I consider the four prongs of Taubes carb/insulin hypothesis, but I've decided to try and summarize this in a blog post.  Another common comment is that I'm somehow nit-picking at minutia, basically if folks lose weight on low carb, it doesn't matter the details of why.  To those, if they are reading this, I would say that any objective view of my arguments would lead to the conclusion that these are NOT minor details, they are the sum total of Taubes' evidence in support of his hypothesis.  Not only has he NEVER debunked the calorie-based theories on obesity, but almost all evidence in support of his "alternate" theory HAS been.  

I will not be referencing this post, it's all been done before here, and I don't have the time to trace down every link etc.  


So, what do the four prongs of the fork stuck in the potato above represent?  
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Friday, May 3, 2013

Revisiting Taubes' Four Facts from the Sixties

In Good Calories Bad Calories, Gary Taubes wrote the somewhat shockingly definitive summary paragraph below (I've separated out the numbered statements for clarity):  
By the mid-1960s, four facts had been established beyond reasonable doubt:
(1) carbohydrates are singularly responsible for prompting insulin secretion;
(2) insulin is singularly responsible for inducing fat accumulation;
(3) dietary carbohydrates are required for excess fat accumulation; and
(4) both Type 2 diabetics and the obese have abnormally elevated levels of  circulating insulin and a “greatly exaggerated” insulin response to carbohydrates in the diet, ... (Kindle Locations 8010-8014)

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Saturday, February 9, 2013

More Hyperinsulinemia, Insulin-Suppressive Drugs & Obesity (and Lustig)

Building on my last post on this topic ...

So far I've spent most of the blogging on a study comparing 3 doses of octreotide, an insulin suppressing drug, vs. placebo in a subset of obese people pre-tested and determined to be insulin hypersecreters as defined by a corrected ratio for insulin to glucose levels.  This post will focus more on two other studies using this drug, perhaps just the first ... let's see how long this gets ;-)    I think it will be easiest to number the 3 studies, all bearing Lustig's name:
I've already discussed the rather unimpressive performance of octreotide in Study 3.  While the highest dose group had the highest "response" rate (20.5% losing ≥5% initial weight), the rates were similar between the placebo group (11.4%) compared to the 40mg octreotide group (12.5%), which is important as this is the dose used in Studies 1&2.   Additionally, mean losses for the entire 40 & 60 mg groups were less than 2%, and even the most promising responders, Caucasian hypersecreters with above median CIR, only lost an average of less than 4% over 6 months.
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Saturday, February 2, 2013

The problem with (NOT) giving medical advice in the Incestral Health Community

Just about every major blogger and guru in the IHC has a lengthy medical disclaimer page.  They are not providing medical advice on the internet because if they are an MD it's illegal (my understanding of the law, feel free to correct me if I'm wrong here),  and if they are not, it's illegal to practice without a license.  Same goes for nutritional advice and all that.  

Right after the medical disclaimer, where you've usually been given the "I have no special training in what I'm about to convey" spiel, or, the flipside, the disclaimer is signed with a name and a litany of letters after it.  And from time to time, you get nothing more than a telling of someone's story on how they cured themselves.  The IHC is big on this.  One of the more recent trends in the IHC is the promotion of ketogenic diets for curing cancer.  I consider this to be wholly irresponsible unless there is a focus on using the diet in conjunction with medical therapies that have been proven effective.  I don't see enough of that in this community, rather too much of the opposite of doctor bashing.  
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Monday, January 28, 2013

Lessons from LIRKO

The LIRKO mouse has no insulin receptors in its liver.  It's one pretty sickly mouse.  In most studies it becomes hyperglycemic and hyperinsulinemic very early in life, but by six months or so of age is either normoglycemic or hypoglycemic.  Despite the concurrent hyperglycemia and hyperinsulinemia, the LIRKO remains normal weight, it is even a bit underweight if anything.  This is despite the fact that  circulating free fatty acids (FFA, or my preferred acronym, NEFA)  are suppressed by 40%.  {Here are the two papers I've discussed in previous blog posts: Loss of Insulin Signaling in Hepatocytes Leads to Severe Insulin Resistance and Progressive Hepatic Dysfunction , High Circulating Leptin Receptors with Normal Leptin Sensitivity in Liver-specific Insulin Receptor Knock-out (LIRKO) Mice both links are to free full texts}

LIRKO presents two problems for the TWICHOOB:
1.  Chronic hyperinsulinemia does not cause rampant fat accumulation 
2.  Insulin "locking away" fats does not lead to hyperphagia (overeating)

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Saturday, January 26, 2013

Will this be NuSI's first experiment?


Watch the first 5 minutes of this video.  In it:

  • Gary says there's 10% error in doubly labeled water measurements (I don't know if it is that high, but it is interesting that this is the level he puts it at)
  • Gary describes an experiment to be done in men (he has stated at other times this is because these diets tend to work better in men, what, insulin doesn't work the same in women?)
  • Gary pitched this to Pennington research center before.  
  • Overfeed by 20% of calories 
  • Describes ketogenic, Atkins diet, as steaks, chops, eggs and bacon.  Gee, I wonder how those misconceptions of the Atkins diet keep getting perpetuated, eh?
  • Gary predicts that energy expenditure will increase in keto group so that they will burn the excess calories.  
Now that Gary has the funding, have they commissioned this study?  If not, what are they waiting for?