LIRKO vs. TWICHOO X.0

from this study, image from this post

It occurred to me as I was thinking again about LIRKO, that this little mouse not only countered TWICHOO 1.0, but it pretty much puts the lid on TWICHOO X.0.  This profoundly hyperglycemic and hyperinsulinemic liver insulin-receptor knockout mouse, is not fat.  Though not statistically significant, the trend is to eat a tad less, be a tad smaller, and pack on fewer fat grams  than controls.  But let's just call it a wash.

For any newer readers, TWICHOO stands for Taubes Wrong Insulin-Carbohydrate Hypothesis Of Obesity.  Version 1.0 was that which was put forth in Good Calories Bad Calories.  In this version, Taubes put forth four ways by which the carbohydrate could promote obesity:

1.  Carbohydrates stimulate insulin which stimulates fat storage and/or traps fats in our fat cells so fat accumulates.

This was pretty much the "lead singer" of his Barbershop Quartet singing the TWICHOO jingle.  Carbs stimulating insulin basically led to chronically elevated insulin levels.  The other three are:

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